Physiologically Based Pharmacokinetic Model of OATP1B Substrates with a Nonlinear Mixed Effect Approach: Estimating Empirical In Vitro-to-In Vivo Scaling Factors.
Rui LiEmi KimotoYi-An BiDavid TessManthena V S VarmaPublished in: Clinical pharmacokinetics (2024)
This study improves the confidence in predicting the pharmacokinetics of OATP1B substrates in individual studies of small sample sizes, and quantifies the variability associated with the prediction.
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