Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists.
Sarah R SpellJohn B MangrumErica J PetersonDaniele FabrisRoger PtakNicholas P FarrellPublished in: Chemical communications (Cambridge, England) (2017)
The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.
Keyphrases
- nucleic acid
- antiretroviral therapy
- hiv positive
- hiv infected
- respiratory syndrome coronavirus
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- sensitive detection
- protein protein
- amino acid
- reduced graphene oxide
- minimally invasive
- binding protein
- coronavirus disease
- south africa
- small molecule
- gold nanoparticles
- molecularly imprinted
- high resolution
- single molecule
- electron transfer