Sodium-glucose cotransporter-2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body-induced NRF2 activation.

Published in: Diabetes, obesity & metabolism (2021)

Dapagliflozin prevented the progression of diabetic kidney disease by inhibiting cellular senescence and oxidative stress via ketone-induced NRF2 activation.

Keyphrases

oxidative stress
diabetic rats
dna damage
high glucose
endothelial cells
type diabetes
wound healing
drug induced
stress induced
ischemia reperfusion injury
signaling pathway
induced apoptosis
endoplasmic reticulum stress