GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity.

Yang HanHongling ZhaoGang LiJin JiaHejiang GuoJinpeng TanXingyao SunSaiyu LiQian RanChenjun BaiYongqing GuZhongJun LiHua GuanShan-Shan Gao Ping-Kun Zhou

Published in: British journal of cancer (2024)

Our study defines K525 crotonylation of DNA-PKcs is important for the DNA-PK complex assembly and DSBs repair activity via NHEJ pathway. Targeting GCN5-mediated K525 Kcr of DNA-PKcs may be a promising therapeutic strategy for improving the outcome of cancer radiotherapy.

Keyphrases

circulating tumor
cell free
single molecule
papillary thyroid
nucleic acid
radiation therapy
circulating tumor cells
squamous cell
locally advanced