Multiparametric functional MRI and 18F-FDG-PET for survival prediction in patients with head and neck squamous cell carcinoma treated with (chemo)radiation.
Roland M MartensThomas KoopmanCristina LaviniMeedie AliCarel F W PeetersDaniel P NoijGerben ZwezerijnenJ Tim MarcusMarije R VergeerC René LeemansRemco de BreePim de GraafRonald BoellaardJonas A CastelijnsPublished in: European radiology (2020)
• Parameters of DWI/IVIM, DCE-MRI, and 18F-FDG-PET/CT were able to capture complementary tumor characteristics. • Multivariable analysis revealed that intoxications, HPV negativity, large tumor volume and high vascular permeability (Ktrans), and extravascular extracellular space (Ve) were complementary predictive for locoregional recurrence. • In addition to predictive parameters for locoregional recurrence, also high cellularity (low ADC) and high metabolism (high SUV) were complementary predictive for overall survival.