Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis.
Lyduine E CollijGemma SalvadóLyduine E CollijSophie E MastenbroekPierre SchoenmakersFiona HeemanLeon AksmanAlle Meije WinkBart N M BerckelWiesje Maria van der FlierPhilip ScheltensPieter Jelle VisserFrederik BarkhofSven HallerJuan-Domingo GispertIsadora Lopes Alvesnull nullPublished in: Neurology (2022)
Whereas a 1-trajectory model recovers the established pattern of amyloid accumulation, SuStaIn determined that 3 subtypes were optimal, showing distinct associations with Alzheimer disease risk factors. Further analyses to determine clinical utility are warranted.
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