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From Inflammation to Current and Alternative Therapies Involved in Wound Healing.

Mariana Barreto SerraWermerson Assunção BarrosoNeemias Neves da SilvaSelma do Nascimento SilvaAntonio Carlos Romão BorgesIracelle Carvalho AbreuMarilene Oliveira da Rocha Borges
Published in: International journal of inflammation (2017)
Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency. Finally, we will discuss the current therapeutic interventions in the wounds treatment, and the alternative therapies used as promising results in the development of new products with healing potential.
Keyphrases
  • wound healing
  • oxidative stress
  • induced apoptosis
  • cell cycle arrest
  • physical activity
  • transcription factor
  • replacement therapy
  • signaling pathway
  • climate change
  • cell death
  • combination therapy
  • smoking cessation