Progression patterns and therapeutic sequencing following immune checkpoint inhibition for HCC: an international observational study.
Thomas TalbotAntonio D'AlessioMatthias PinterLorenz BalcarBernhard ScheinerThomas U MarronTomi JunSirish DharmapuriCelina AngAnwaar SaeedHannah HildebrandMahvish MuzaffarClaudia A M FulgenziSuneetha AmaraAbdul Rafeh NaqashAnuhya GampaAnjana PillaiYinghong WangUqba KhanPei-Chang LeeYi-Hsiang HuangBertram BengschDominic BettingerYehia I MohamedAhmed KasebTiziana PressianiNicola PersoneniLorenza RimassaNaoshi NishidaMasatoshi KudoArndt WeinmannPeter Robert GalleAmbreen MuhammedAlessio CortelliniArndt VogelDavid James PinatoPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
ICI-TKI sequencing is a consolidated option in advanced HCC. nVI and IHG predict poorer prognosis. Despite lack of recommendation, continuation of ICI beyond progression in HCC is adopted clinically: future efforts should appraise which patients benefit from this approach.