Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood.
Min-Yi TaoXin LiuZi-Lin ChenMeng-Nan YangYa-Jie XuHua HeFang FangQian ChenXuan-Xia MaoJun ZhangFengxiu OuyangXiu-Hua ShenFei LiZhong-Cheng Luonull nullXiaoming ShenHong HuangKun SunJun ZhangWeiye WangWeiping XuFengxiu OuyangFei LiYin HuangJinsong ZhangChonghuai YanLisong ShenYixiao BaoYing TianWeiwei ChenHuijuan ZhangChuanliang TongJian XuLin ZhangYiwen ZhangFang JiangXiaodan YuGuangjun YuJinjin ChenYu ZhangXiaotian LiHaidong ChengQinying ZhangTao DuanJing HuaHua PengPublished in: Pediatric research (2024)
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood, but little is known about how weight trajectories during infancy affect adiposity during early childhood in LGA subjects. The study is the first to demonstrate a greater impact of high-growth weight trajectory during infancy (0-2 years) on adiposity in early childhood (at age 4 years) in subjects with fetal overgrowth (LGA) than in those with normal birth size (appropriate-for-gestational age). Weight trajectory monitoring may be a valuable tool in identifying high-risk LGA children for close follow-ups and interventions to decrease the risk of obesity.