Deficiency of Trex1 leads to spontaneous development of type 1 diabetes.

Jiang-Man ZhaoZhi-Hui SuQiu-Ying HanMiao WangXin LiuJing LiShao-Yi HuangJing ChenXiao-Wei LiXia-Ying ChenZeng-Lin GuoShuai JiangJie PanTao LiWen XueTao Zhou

Published in: Nutrition & metabolism (2024)

Our study links the DNA-induced chronic inflammation to the pathogenesis of type 1 diabetes, and also provides an animal model for type 1 diabetes studies.

Keyphrases

type diabetes
oxidative stress
high glucose
diabetic rats
cardiovascular disease
drug induced
circulating tumor
cell free
metabolic syndrome
replacement therapy
nucleic acid