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Cumulative use of therapeutic bladder anticholinergics and the risk of dementia in patients with lower urinary tract symptoms: a nationwide 12-year cohort study.

Yi-Chi WangYung-Liang ChenChun-Che HuangChung-Han HoYu-Tung HuangMing-Ping WuMing-Jung OuChiu-Hsien YangPing-Jen Chen
Published in: BMC geriatrics (2019)
Our study indicates that higher cumulative anticholinergic exposure is associated with an increase in the risk of incident dementia in patients with LUTS aged 50 years of age and over. Either using one anticholinergic agent or switching anticholinergic agents cumulatively increases this risk. Therapeutic risks and benefits of using anticholinergics in LUTS treatment should be clinically reviewed and weighed.
Keyphrases
  • lower urinary tract symptoms
  • benign prostatic hyperplasia
  • mild cognitive impairment
  • cognitive impairment
  • cardiovascular disease
  • spinal cord injury
  • type diabetes
  • human health
  • combination therapy
  • climate change