Inositol hexaphosphate promotes intestinal adaptation in short bowel syndrome via an HDAC3-mediated epigenetic pathway.
Weipeng WangYing WangYing LuXinbei TianShanshan ChenBo WuJun DuYongtao XiaoWei Cai
Published in: Food & nutrition research (2023)
IP6 treatment promotes intestinal adaptation in rats with SBS. IP6 is metabolized to IP3 to increase HDAC3 activity to regulate the FOXO3/CCND1 signaling pathway and may represent a potential therapeutic approach for patients with SBS.