Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer.

Xinlei HuKai LuoHui ShiXiaoqin YanRuichen HuangBi ZhaoJun ZhangDan XieWei Zhang

Published in: Clinical epigenetics (2022)

Both the 5hmC signal and fragmentation profiles in 5hmC cfDNA data are sensitive and effective in lung cancer detection and could be incorporated into the diagnostic model to achieve good performance, promoting research focused on clinical diagnostic models based on cfDNA 5hmC data.

Keyphrases

electronic health record
big data
genome wide
machine learning
data analysis
artificial intelligence