Targeting Mitochondrial Complex I Deficiency in MPP + /MPTP-induced Parkinson's Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene.

Hongzhi LiJing ZhangYuqi ShenYifan YeQingyou JiangLan ChenBohao SunZhuo ChenLuxi ShenHezhi FangJifeng YangHaihua Gu

Published in: Biological procedures online (2024)

/MPTP-induced models, and vastly alleviates MPTP-induced toxic effect on dopaminergic neurons. Our study may provide a basis for gene therapy of sporadic PD with defective complex I caused by MPTP-like substance.

Keyphrases

high glucose
diabetic rats
oxidative stress
mouse model
drug induced
spinal cord
drug delivery
spinal cord injury
late onset
cancer therapy
early onset
genome wide analysis