Neuroinflammation and Epilepsy: From Pathophysiology to Therapies Based on Repurposing Drugs.
Pascual SanzTeresa RubioMaria Adelaida Garcia-GimenoPublished in: International journal of molecular sciences (2024)
Neuroinflammation and epilepsy are different pathologies, but, in some cases, they are so closely related that the activation of one of the pathologies leads to the development of the other. In this work, we discuss the three main cell types involved in neuroinflammation, namely (i) reactive astrocytes, (ii) activated microglia, and infiltration of (iii) peripheral immune cells in the central nervous system. Then, we discuss how neuroinflammation and epilepsy are interconnected and describe the use of different repurposing drugs with anti-inflammatory properties that have been shown to have a beneficial effect in different epilepsy models. This review reinforces the idea that compounds designed to alleviate seizures need to target not only the neuroinflammation caused by reactive astrocytes and microglia but also the interaction of these cells with infiltrated peripheral immune cells.
Keyphrases
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- inflammatory response
- cognitive impairment
- cerebral ischemia
- anti inflammatory
- induced apoptosis
- temporal lobe epilepsy
- neuropathic pain
- subarachnoid hemorrhage
- cerebrospinal fluid
- blood brain barrier
- cell therapy
- drug induced
- cell proliferation
- spinal cord