Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda.

Isaac SsewanyanaEmmanuel ArinaitweJoaniter I NankabirwaAdoke YekaRichard SullivanMoses R KamyaPhilip J RosenthalGrant DorseyHarriet Mayanja-KizzaChris DrakeleyBryan GreenhouseKevin K A Tetteh

Published in: Malaria journal (2017)

Avidity to two different P. falciparum antigens was lower in areas of high transmission intensity compared to areas with lower transmission. Appreciation of the mechanisms behind these findings as well as their clinical consequences will require additional investigation, ideally utilizing longitudinal data and investigation of a broader array of responses.

Keyphrases

high intensity
high resolution
electronic health record
dendritic cells
high throughput
machine learning
mass spectrometry
plasmodium falciparum