Detecting hypodiploidy with endoreduplication and masked hypodiploidy in B-cell acute lymphoblastic leukemia using multicolor flow cytometry.
Anumeha ChaturvediDhanalaxmi ShettySitaram Gundu GhogaleNilesh DeshpandeYajamanam BadrinathGaurav ChatterjeeKarishma GiraseHarshini SriramTwinkle KhankaChetna MishraNiharika DasguptaSejal Anil GujarathiSweta RajpalNikhil PatkarPrathibha Amare-KadamSumeet GujralPapagudi Ganesan SubramanianPrashant Ramesh TembharePublished in: Cytometry. Part B, Clinical cytometry (2022)
MFC-ploidy analysis shows a characteristic pattern of DNA-ploidy in samples with endoreduplication. It allows the distinction between samples with masked hypodiploidy from true hyperdiploidy. An integrated approach involving cytogenetic and MFC-ploidy detection is very helpful in the risk stratification of B-ALL in routine clinical practice.