Wnt pathway modulation generates blastomere-derived mouse embryonic stem cells with different pluripotency features.
Marta Vila-CejudoSandra Alonso-AlonsoAnna PujolJosep SantalóElena IbáñezPublished in: Journal of assisted reproduction and genetics (2020)
Wnt and MAPK pathways have a key role in the successful derivation and pluripotency features of mESC from single precompaction blastomeres. Modulation of these pathways results in mESC lines with various degrees of naïve-like and primed-like pluripotency features.