Metabolic Regulation of Methionine Restriction in Diabetes.
Jie YinWenkai RenShuai ChenYuying LiHui HanJing GaoGang LiuXin WuTiejun LiSung Woo KimYulong YinPublished in: Molecular nutrition & food research (2018)
Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.
Keyphrases
- oxidative stress
- amino acid
- type diabetes
- insulin resistance
- cardiovascular disease
- glycemic control
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- diabetic rats
- adipose tissue
- cell death
- endoplasmic reticulum stress
- magnetic resonance
- weight loss
- blood glucose
- high resolution
- computed tomography
- protein protein
- small molecule
- heat shock protein
- polycystic ovary syndrome
- high fat diet induced