Synergistic effects of EMPs and PMPs on pulmonary vascular leakage and lung injury after ischemia/reperfusion.

Jie ZhangYu ZhuYue WuQing-Guang YanXiao-Yong PengXin-Ming XiangMing-Ying XueQing-Hui LiLiang-Ming LiuTao Li

Published in: Cell communication and signaling : CCS (2020)

EMPs and PMPs contribute to the pulmonary vascular leakage and lung injury after I/R. EMPs mediate pulmonary sequestration of platelets, producing more PMPs to play synergistic effect. Mechanically, EMPs carrying miR-155 that down-regulates ZO-1 and claudin-5 and PMPs carrying miR-126 that up-regulates Cav-1, synergistically mediate pulmonary vascular leakage and lung injury after I/R. Video Abstract.

Keyphrases

pulmonary hypertension
cell proliferation
long non coding rna
long noncoding rna
cancer therapy