Intraoperative near-infrared imaging can identify canine mammary tumors, a spontaneously occurring, large animal model of human breast cancer.
Andrew NewtonJarrod PredinaMichael MisonJeffrey RungeCharles BradleyDarko StefanovskiSunil SinghalDavid E HoltPublished in: PloS one (2020)
Systemic ICG accumulates reliably in malignant canine mammary tumors > 2 cm. Although no tumor margins fluoresced, a wider margin of normal tissue is removed in canine mastectomy, making direct comparisons with breast conserving surgery difficult. Targeted NIR imaging agents are likely required to improve detection of smaller tumors and improve the specificity of NIR imaging for residual disease and metastatic lymph node detection.
Keyphrases
- high resolution
- fluorescence imaging
- lymph node
- photodynamic therapy
- endothelial cells
- small cell lung cancer
- squamous cell carcinoma
- minimally invasive
- neoadjuvant chemotherapy
- loop mediated isothermal amplification
- coronary artery disease
- label free
- real time pcr
- cancer therapy
- mass spectrometry
- young adults
- induced pluripotent stem cells
- acute coronary syndrome
- percutaneous coronary intervention
- atrial fibrillation