Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.
Irene Santos-GarcíaCarmen Rodríguez-CuetoPatricia VillegasFabiana PiscitelliAnna LauritanoChe-Kun J ShenVincenzo Di MarzoJavier Fernández-RuizEva de LagoPublished in: Journal of neuroinflammation (2023)
Our data confirmed the potential of elevating the endocannabinoid tone as a therapy against TDP-43-induced neuropathology in FTD, limiting glial reactivity, preserving neuronal integrity and improving cognitive, emotional and social deficits.
Keyphrases
- amyotrophic lateral sclerosis
- cerebral ischemia
- high glucose
- diabetic rats
- traumatic brain injury
- healthcare
- electronic health record
- cell therapy
- mental health
- drug induced
- neuropathic pain
- oxidative stress
- stem cells
- endothelial cells
- deep learning
- climate change
- risk assessment
- artificial intelligence
- stress induced