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Distinct dopaminergic abnormalities in traumatic brain injury and Parkinson's disease.

Peter Owen JenkinsAndreas-Antonios RoussakisSara De SimoniNiall J BourkeJessica FlemingerJames ColePaola PicciniDavid James Sharp
Published in: Journal of neurology, neurosurgery, and psychiatry (2020)
The results show that patients with early PD and TBI have distinct patterns of striatal dopamine abnormalities. Patients with early PD and moderate/severe TBI showed similar reductions in caudate DaT binding, but patients with PD showed a greater reduction in putamen DaT and a lower putamen to caudate ratio. The results suggest that parkinsonian motor signs are absent in these patients with TBI because of relatively intact putaminal dopamine levels.
Keyphrases
  • traumatic brain injury
  • severe traumatic brain injury
  • uric acid
  • functional connectivity
  • parkinson disease
  • metabolic syndrome
  • deep brain stimulation