The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.
Wojciech K PanekR G ToedebuschBridget E McLaughlinPeter J DickinsonJ E Van DykeKevin D WoolardMichael E BerensMaciej S LesniakB K SturgesKaren M VernauC LiJason M MiskaChristine M ToedebuschPublished in: Journal of neuro-oncology (2024)
Our study validates CCL2-CCR4 as a bi-directional Treg-glioma immunosuppressive and tumor-promoting axis in canine high-grade glioma.