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The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.

Wojciech K PanekR G ToedebuschBridget E McLaughlinPeter J DickinsonJ E Van DykeKevin D WoolardMichael E BerensMaciej S LesniakB K SturgesKaren M VernauC LiJason M MiskaChristine M Toedebusch
Published in: Journal of neuro-oncology (2024)
Our study validates CCL2-CCR4 as a bi-directional Treg-glioma immunosuppressive and tumor-promoting axis in canine high-grade glioma.
Keyphrases
  • high grade
  • dendritic cells
  • regulatory t cells
  • liver fibrosis
  • liver injury
  • gene expression
  • transcription factor