Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease.

Neus FalgàsMarta Peña-GonzálezAndrea Val-GuardiolaAgnès Pérez-MillanNúria GuillénJordi SartoDiana EstellerBeatriz BoschGuadalupe Fernández-VillullasAdrià Tort-MerinoGerard MayàJosep Maria AugéAlex IranzoMircea BalasaAlbert LladóManuel Morales-RuizNúria BargallóEmma Muñoz-MorenoLea T GrinbergRaquel Sánchez-Valle

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

LC degeneration is greater in early-onset AD (EOAD) compared to late-onset AD. Tau-derived LC degeneration drives a higher severity of neuropsychiatric symptoms. EOAD harbors a more profound selective vulnerability of the LC system. LC degeneration is associated with an increase of cerebrospinal fluid noradrenaline levels in AD.

Keyphrases

late onset
early onset
cerebrospinal fluid
simultaneous determination
mass spectrometry
liquid chromatography
climate change
physical activity
mild cognitive impairment