Alterations in the sarcopenia index are associated with inflammation, gut, and oral microbiota among heart failure, left ventricular assist device, and heart transplant patients.
Melana YuzefpolskayaBruno BohnAnnamaria LadanyiAlberto PinsinoLorenzo BraghieriMatthew R CareyKevin ClerkinGabriel T SayerFarhana LatifTakeda KojiNir UrielRenu NandakumarAnne-Catrin UhlemannPaolo C ColomboRyan T DemmerPublished in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2024)
SI levels decreased in symptomatic HF and remained decreased long-term after LVAD and HT. In the combined cohort, SI levels covaried with inflammation in a similar fashion and were significantly related to overall microbial (gut and oral) diversity, including specific taxa compositional changes.