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Dietary emulsifier polysorbate-80-induced small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis.

Hirotaka FuruhashiMasaaki HigashiyamaYoshikiyo OkadaChie KuriharaAkinori WadaKazuki HoriuchiYoshinori HanawaAkinori MizoguchiShin NishiiKenichi InabaNao SugiharaChikako WatanabeShunsuke KomotoKengo TomitaSoichiro MiuraRyota Hokari
Published in: Journal of gastroenterology and hepatology (2019)
Polysorbate-80 enhances the vulnerability of the small intestine to indomethacin-induced injury by inducing ileal dysbiosis. Direct enhancement of the motility of specific flagellated microbiota by P80 might be related to dysbiosis and intestinal injury.
Keyphrases
  • high glucose
  • diabetic rats
  • climate change
  • drug induced
  • oxidative stress
  • endothelial cells
  • escherichia coli