Dietary emulsifier polysorbate-80-induced small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis.

Hirotaka FuruhashiMasaaki HigashiyamaYoshikiyo OkadaChie KuriharaAkinori WadaKazuki HoriuchiYoshinori HanawaAkinori MizoguchiShin NishiiKenichi InabaNao SugiharaChikako WatanabeShunsuke KomotoKengo TomitaSoichiro MiuraRyota Hokari

Published in: Journal of gastroenterology and hepatology (2019)

Polysorbate-80 enhances the vulnerability of the small intestine to indomethacin-induced injury by inducing ileal dysbiosis. Direct enhancement of the motility of specific flagellated microbiota by P80 might be related to dysbiosis and intestinal injury.

Keyphrases

high glucose
diabetic rats
climate change
drug induced
oxidative stress
endothelial cells
escherichia coli