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Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma.

Agustin SgroJoseph CursonsCharlene WaryahEleanor A WoodwardMomeneh ForoutanRuqian LyuGeorge C T YeohPeter J LeedmanPilar Blancafort
Published in: Clinical epigenetics (2023)
By combining multiple effector domains, we demonstrate the utility of a CRISPRa toolbox of epigenetic effectors and gRNAs for patient-specific treatment of aggressive HCC.
Keyphrases
  • dna methylation
  • gene expression
  • genome wide
  • type iii
  • dendritic cells
  • regulatory t cells
  • stem cells
  • transcription factor
  • mesenchymal stem cells
  • bone marrow
  • replacement therapy