Efficient Charge-Transfer Studies for Selective Detection of Bilirubin Biomolecules Using CsPbBr 3 as the Fluorescent Probe.
Sumit KumarSukanya GhoshPrasenjit KarPublished in: The journal of physical chemistry. B (2023)
Bright luminescence hybrid halide perovskite nanocrystals (PNCs) as a novel fluorophore class have not been broadly explored in biological sensing. Herein, we synthesized highly fluorescent CsPbBr 3 PNCs through the LARP method using oleic acid and oleyl amine as capping ligands. Morphological and optical properties of as-synthesized PNCs were studied using transmission electron microscopy, X-ray diffraction, UV-vis, and emission spectroscopic analysis. Oleic acid- and oleyl amine-capped PNCs are employed for sensitive and selective detection of bilirubin (BR). A panel of characterizations (time-correlated single-photon count spectroscopy and photoluminescence (PL)) was carried out to investigate the detailed sensing study of PNCs-BR composite for quenching the PL emission of CsPbBr 3 with BR. It has been noticed that the synthesized nanoparticles are highly capable of detecting BR and thus act as a biological material sensor.
Keyphrases
- fluorescent probe
- electron microscopy
- living cells
- quantum dots
- energy transfer
- label free
- solid state
- loop mediated isothermal amplification
- high resolution
- room temperature
- real time pcr
- molecular docking
- single molecule
- sensitive detection
- magnetic resonance imaging
- light emitting
- peripheral blood
- case control
- ionic liquid