Immunogenicity and safety of heterologous boost immunization with PastoCovac Plus against COVID-19 in ChAdOx1-S or BBIBP-CorV primed individuals.

Sana EybpooshAlireza BiglariRahim SorouriFatemeh AshrafianMona Sadat LarijaniVicente Verez-BencomoMaria Eugenia Toledo-RomaniCarmen Valenzuela SilvaMostafa Salehi-VaziriSarah DahmardehDelaram DoroudMohammad BanifazlEhsan MostafaviAnahita BavandAmitis Ramezani

Published in: PLoS pathogens (2023)

PastoCovac Plus booster application in primed individuals with BBIBP-CorV or ChAdOx1-S successfully increased specific antibodies' levels without any serious adverse events. This vaccine could be administrated in the heterologous regimen to effectively boost humoral immune responses.

Keyphrases

immune response
coronavirus disease
sars cov
saccharomyces cerevisiae
dendritic cells
toll like receptor
respiratory syndrome coronavirus