Cluster headache genome-wide association study and meta-analysis identifies eight loci and implicates smoking as causal risk factor.
Bendik Slagsvold WinsvoldAster V E HarderCaroline RanMona A ChalmerMaria Carolina DalmassoEgil FerkingstadKumar Parijat TripathiElena BacchelliSigrid BørteCarmen FourierAnja S PetersenLisanne S VijfhuizenSigurdur H MagnussonEmer O'ConnorGyda BjornsdottirPaavo HäppöläYen-Feng WangIda CallesenTim KeldermanVictor J GallardoIrene de BoerFelicia Jennysdotter OlofsgårdKatja HeinzeNunu LundLaurent F ThomasChia-Lin HsuMatti PirinenHeidi HautakangasMarta RibasésSimona GuerzoniPrasanth SivakumarJanice YipAxel HeinzeFahri KüçükaliSisse R OstrowskiOle B PedersenEspen Saxhaug KristoffersenAmy E MartinsenMaría S ArtigasSusie LagrataMaria Michela CainazzoJoycee AdebimpeOlivia QuinnCarl GöbelAnna CirkelAlexander E VolkStefanie Heilmann-HeimbachAnne Heidi SkogholtMaiken E GabrielsenLeopoldine A WilbrinkDaisuke DannoDwij MehtaDaníel F Guðbjartssonnull nullFrits R RosendaalKo Willems van DijkRolf FronczekMichael WagnerMartin SchererHartmut GöbelKristel SleegersOlafur A SveinssonLuca PaniMichele ZoliJosep A Ramos-QuirogaEfthimios DardiotisAnna SteinbergSteffi Riedel-HellerChristina SjöstrandThorgeir E ThorgeirssonHreinn StefanssonLaura SouthgateRichard C TrembathJana VandrovcovaRaymond NoordamKoen PaemeleireKari StefanssonCathy Shen-Jang FannElisabet WaldenlindErling TronvikRigmor H JensenShih-Pin ChenHenry HouldenGisela M TerwindtChristian KubischElena MaestriniMichail VikelisPatricia Pozo-RosichAndrea C BelinManjit MatharuArn M J M van den MaagdenbergThomas F HansenAlfredo RamirezJohn-Anker Zwartnull nullPublished in: Annals of neurology (2023)
This first genome-wide association study meta-analysis gives clues to the biological basis of cluster headache and indicates that smoking is a causal risk factor. This article is protected by copyright. All rights reserved.