Two ways of epigenetic silencing of TFPI2 in cervical cancer.

Alexandra Fullár Katalin KarasziPéter HollósiGábor LendvaiLászlóné OláhAndrea ReszegiZoltán PappGábor SobelJózsef DudásIlona Kovalszky

Published in: PloS one (2020)

These results indicate dual epigenetic inhibition of TFPI2 on the transcription level by promoter methylation in cancer cells and on the translation level by miR-23a in tumor-associated fibroblasts. As a consequence, inactivation of the TFPI2 gene plays a strategic role in the progression of cervical cancer.

Keyphrases

dna methylation
genome wide
gene expression
transcription factor
cell proliferation
copy number
long non coding rna
long noncoding rna
extracellular matrix
genome wide identification
genome wide analysis