Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.

Fei WangChunxi WangYaping LiuWenxian LanHao HanRenxiao WangShaohua HuangChunyang Cao

Published in: Chemical communications (Cambridge, England) (2020)

G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

Keyphrases

magnetic resonance
solid state
high resolution
dna methylation
circulating tumor
gene expression
transcription factor
cell free
single molecule
stem cells
protein kinase
mass spectrometry
bone marrow
nucleic acid
cell therapy