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p53 at the crossroads of tumor immunity.

Gizem EfeAnil K RustgiCarol Prives
Published in: Nature cancer (2024)
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent studies are beginning to unravel how wild-type and mutant p53 work in distinct ways to modulate tumor immunity. This sets up a disequilibrium between tumor immunosurveillance and escape therefrom. The ability to exploit this emerging knowledge for translational approaches may shape immunotherapy and targeted therapeutics in the future, especially in combinatorial settings.
Keyphrases
  • wild type
  • single cell
  • cell therapy
  • healthcare
  • gene expression
  • small molecule
  • cancer therapy
  • drug delivery
  • bone marrow
  • case control