Potential role of Lu/BCAM in HIV-related atherosclerosis.
Modisa S MotswalediIshmael KasvosveOluwafemi Omoniyi OguntibejuPublished in: African journal of laboratory medicine (2019)
Atheromatous lesions are formed by macrophages and low-density lipoprotein cholesterol invading the vascular intima. Here we show that increasing cholesterol levels are associated with peripheral monocyte depletion and this imbalance is aggravated by carriage of Lu/BCAM leukocyte adhesion molecules. This is true only in HIV infection and probably explains the risk of atherosclerosis observed in HIV-positive patients.
Keyphrases
- hiv positive
- antiretroviral therapy
- men who have sex with men
- hiv infected
- south africa
- human immunodeficiency virus
- end stage renal disease
- hiv testing
- hiv aids
- cardiovascular disease
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- hepatitis c virus
- prognostic factors
- peripheral blood
- type diabetes
- patient reported outcomes
- cardiovascular risk factors
- metabolic syndrome
- biofilm formation
- low density lipoprotein
- drug induced
- staphylococcus aureus