The selective serotonin reuptake inhibitor fluoxetine has direct effects on beta cells, promoting insulin secretion and increasing beta-cell mass.
Liu BoInmaculada Ruz-MaldonadoKlaudia ToczyskaOladapo E OlaniruMohammed Gulrez ZariwalaDavid HopkinsMin ZhaoShanta J PersaudPublished in: Diabetes, obesity & metabolism (2022)
These data are consistent with a role for fluoxetine in regulating glucose homeostasis through direct effects on beta cells. Fluoxetine thus demonstrates promise as a preferential antidepressant for patients with concomitant occurrence of depression and diabetes.
Keyphrases
- bipolar disorder
- induced apoptosis
- cell cycle arrest
- type diabetes
- cardiovascular disease
- big data
- endoplasmic reticulum stress
- risk assessment
- depressive symptoms
- metabolic syndrome
- signaling pathway
- cell death
- electronic health record
- blood glucose
- cell therapy
- mesenchymal stem cells
- blood pressure
- glycemic control
- deep learning
- machine learning
- sleep quality
- physical activity