Novel approach to idursulfase and laronidase desensitization in type 2 and type 1 S mucopolysaccharidosis (MPS).
Federico SpataroFabio ViggianiDomenico Giorgio MacchiaValentina RolloAlbina TummoloPatrizia SuppressaCarlo Sabba'Maria Pia RossiLucia GilibertiFrancesco SatrianoEustachio NettisDanilo Di BonaMaria Filomena CaiaffaRita FischettoLuigi MacchiaPublished in: Orphanet journal of rare diseases (2022)
Rapid desensitization is a suitable and safe option in the case of idursulfase and laronidase allergy. Combination with subcutaneous allergen immunotherapy-like desensitization afforded restoration of enzyme replacement therapy given by the normal administration schedule, by inducing sustained tolerance.