Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture.
Huimin YanYing HuYang LyuAntonina AkkAngela C HirbeSamuel A WicklineHua PanElisha D O RobersonChristine T N PhamPublished in: bioRxiv : the preprint server for biology (2024)
These results confirm that SOD2 is key modulator of oxidative stress in AAA. This nanotherapeutic mRNA delivery approach may find translational application in the medical management of small AAA and the prevention of AAA rupture.