The G protein-coupled receptor ligand apelin-13 ameliorates skeletal muscle atrophy induced by chronic kidney disease.

Yuki EnokiTomoya NagaiYuna HamamuraSumika OsaHideaki NakamuraKazuaki TaguchiHiroshi WatanabeToru MaruyamaKazuaki Matsumoto

Published in: Journal of cachexia, sarcopenia and muscle (2022)

This study demonstrated for the first time the association of the Apj endogenous ligand-uraemic toxin axis with skeletal muscle atrophy in CKD and the utility of therapeutic targeting of the apelin-Apj system.

Keyphrases

skeletal muscle
chronic kidney disease
end stage renal disease
insulin resistance
escherichia coli
type diabetes
drug delivery