Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.

Viviane Lamim Lovatel Cecilia de Souza Fernandez Eliane Ferreira Rodrigues Rita de Cássia Barbosa Tavares Elaine Sobral da Costa Eliana Abdelhay Sheila Coelho Soares Lima Teresa de Souza Fernandez Seixas

Published in: Cancer management and research (2020)

Our results suggest that the overexpression of DNMTs and an imbalance between the expressions of the DNA methylation/demethylation machinery components play an important role in MDS development and evolution to AML. These results have clinical implications indicating the importance of DNMTs inhibitors for preventing or delaying the progression to leukemia in pediatric MDS patients.

Keyphrases

dna methylation
end stage renal disease
acute myeloid leukemia
gene expression
genome wide
ejection fraction
newly diagnosed
chronic kidney disease
cell proliferation
prognostic factors
transcription factor
patient reported outcomes
acute lymphoblastic leukemia
patient reported