Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.
Viviane Lamim LovatelCecilia de Souza FernandezEliane Ferreira RodriguesRita de Cássia Barbosa TavaresElaine Sobral da CostaEliana AbdelhaySheila Coelho Soares LimaTeresa de Souza FernandezPublished in: Cancer management and research (2020)
Our results suggest that the overexpression of DNMTs and an imbalance between the expressions of the DNA methylation/demethylation machinery components play an important role in MDS development and evolution to AML. These results have clinical implications indicating the importance of DNMTs inhibitors for preventing or delaying the progression to leukemia in pediatric MDS patients.