Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice.
Maria JelinicNicola KahlbergChen Huei LeoHooi Hooi NgSarah RosliMinh DeoMandy LiSiobhan FinlaysonJesse WalshLaura J ParryRebecca H RitchieChengxue Helena QinPublished in: British journal of pharmacology (2020)
Our study provided the first evidence that endogenous AnxA1 may play an important vasoprotective role in the context of insulin-resistance. AnxA1-based therapies may provide additional benefits over traditional anti-inflammatory strategies for reducing vascular injury in diabetes.