Diagnostic Performance of GFAP, UCH-L1, and MAP-2 Within 30 and 60 Minutes of Traumatic Brain Injury.

Linda PapaW Ian McKinleyAlex B ValadkaZachary C NewmanRachel K NordgrenPierce E PramukaClaire E BarbosaAlexandra M P BritoLindsey J LossLuis Tinoco-GarciaH E HinsonMartin A SchreiberSusan E Rowell

Published in: JAMA network open (2024)

In this cohort study of prehospital patients with TBI, GFAP, UCH-L1, and MAP-2 measured within 30 and 60 minutes of injury were significantly associated with traumatic intracranial lesions and diffuse injury severity on CT scan, 24-hour NSI, and 7-day CIEO. GFAP was the strongest independent marker associated with all outcomes. This study sets a precedent for the early utility of GFAP in the first 30 minutes from injury in future clinical and research endeavors.

Keyphrases

traumatic brain injury
computed tomography
spinal cord injury
blood pressure
high density
severe traumatic brain injury
dual energy
current status
low grade
metabolic syndrome
positron emission tomography
trauma patients
image quality
optic nerve
high grade
optical coherence tomography