Oligodendrocyte-derived exosomes-containing SIRT2 ameliorates depressive-like behaviors and restores hippocampal neurogenesis and synaptic plasticity via the AKT/GSK-3β pathway in depressed mice.
Honghan ZhangXin-Hui XieShu-Xian XuChao WangSiqi SunXinhua SongRuiling LiNingyuan LiYuqi FengHao DuanDi LiZhong-Chun LiuPublished in: CNS neuroscience & therapeutics (2024)
This study establishes how ODEXs improve depressive-like behaviors and hippocampal neuroplasticity and might provide a promising therapeutic approach for depression.
Keyphrases
- cerebral ischemia
- signaling pathway
- bipolar disorder
- mesenchymal stem cells
- stress induced
- stem cells
- depressive symptoms
- cell proliferation
- oxidative stress
- type diabetes
- ischemia reperfusion injury
- temporal lobe epilepsy
- adipose tissue
- metabolic syndrome
- skeletal muscle
- brain injury
- subarachnoid hemorrhage
- insulin resistance