Periostin-TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer.

Bin LiuTiantian WuBiyu LinXingxing LiuYingfu LiuGang SongChuannan FanGaoliang Ouyang

Published in: British journal of cancer (2023)

POSTN and TGF-β1 cooperatively contribute to the tumour-stroma crosstalk by forming a supporting fibrotic microenvironment to promote liver metastasis of CRC cells via the POSTN/integrin/FAK/ERK/STAT3/TGF-β axis in tumour cells and TGF-β/Smad/POSTN signalling in activated HSCs.

Keyphrases

transforming growth factor
induced apoptosis
cell cycle arrest
epithelial mesenchymal transition
squamous cell carcinoma
cell proliferation
stem cells
pi k akt
systemic sclerosis