Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood.
Beckey TrinhSabrina FaleschiniAndrea Cortes HidalgoSheryl L Rifas-ShimanAndrea A BaccarelliDawn L DeMeoAugusto A LitonjuaAlexander NeumannJanine F FelixVincent W V JaddoeHanan El MarrounHenning TiemeierEmily OkenMarie-France HivertHeather H BurrisPublished in: Clinical epigenetics (2019)
The ZNF575 gene is involved in transcriptional regulation but specific functions are largely unknown. Given the widespread use of antidepressants in pregnancy, as well as the effects of exposure to anxiety and depression, implications of potential fetal epigenetic programming by these risk factors and their impacts on development merit further investigation.
Keyphrases
- dna methylation
- pregnancy outcomes
- genome wide
- risk factors
- major depressive disorder
- pregnant women
- copy number
- gene expression
- birth weight
- gestational age
- high fat diet
- preterm birth
- bipolar disorder
- human health
- genome wide identification
- type diabetes
- risk assessment
- physical activity
- insulin resistance
- climate change
- weight loss
- body mass index