Placental Inflammation Leads to Abnormal Embryonic Heart Development.
Eleanor J WardSerena BertSilvia FantiKerri M MaloneRobert T MaughanChristina GkantsinikoudiFabrice PrinLia Karina VolpatoAnna Paula PiovezanGerard J GrahamNeil P DuftonMauro PerrettiFederica M Marelli-BergSuchita NadkarniPublished in: Circulation (2022)
Taken together, these observations provide a mechanistic paradigm whereby neutrophil-driven inflammation in pregnancy can preclude normal embryonic heart development as a direct consequence of poor placental development, which has major implications on cardiac function into adult life.