Skin DNA methylation profile in atopic dermatitis patients: A case-control study.
Olga Yurievna OlisovaNikolai Georgievich KocherginLyailya N KayumovaTatiana M ZavarykinaAlexey A DmitrievAliy Yu AsanovPublished in: Experimental dermatology (2019)
Atopic dermatitis (AD) is a worldwide disease with a complex aetiology. Both genetic and environmental factors cause a predisposition to AD. DNA methylation may be an additional predisposing factor. The goal of our study was to investigate genome-wide methylation profiles of skin from patients with AD and healthy persons. This case-control study included 12 AD patients and 6 healthy volunteers. DNA methylation levels in skin samples were analysed using the Illumina Infinium HumanMethylation450 BeadChip. We found that the methylation profile of skin from patients with AD was significantly different from that of healthy controls. Differential DNA methylation was observed for genes involved in a number of AD-related processes including regulation of the immune response, activation of lymphocytes, cell proliferation, apoptosis and differentiation of the epidermis. Our study indicates the involvement of epigenetic regulation in the development of atopic dermatitis.
Keyphrases
- dna methylation
- genome wide
- atopic dermatitis
- end stage renal disease
- gene expression
- immune response
- cell proliferation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- copy number
- peritoneal dialysis
- oxidative stress
- cell death
- patient reported outcomes
- cell cycle
- dendritic cells
- patient reported
- drug induced