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Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy.

Hila Ben-YehudaMichal AradJavier María Peralta RamosEfrat SharonGiulia CastellaniShir FerreraLiora CahalonSarah Phoebeluc ColaiutaTomer-Meir SalameMichal Schwartz
Published in: Molecular neurodegeneration (2021)
The CCR2/CCL2 axis is required to modify pathology using PD-L1 blockade in a mouse model of tauopathy. This modification involves, in addition to monocytes, the accumulation of FOXP3+ regulatory CD4+ T cells in the brain, and the T-cell chemoattractant, Cxcl12.
Keyphrases
  • mouse model
  • regulatory t cells
  • dendritic cells
  • liver fibrosis
  • liver injury
  • drug induced
  • resting state
  • transcription factor
  • white matter
  • peripheral blood
  • functional connectivity
  • multiple sclerosis