Heterogeneity in Preclinical Alzheimer's Disease Trial Cohort Identified by Image-based Data-Driven Disease Progression Modelling.

Cameron Shand Pawel J Markiewicz David M Cash Daniel C Alexander Michael C Donohue Frederik Barkhof Neil P Oxtobynull null

Published in: medRxiv : the preprint server for health sciences (2023)

Data-driven disease progression modelling of screening MRI scans can predict heterogeneity in cognitive performance/decline and potentially reduce heterogeneity in future clinical trials.

Keyphrases

clinical trial
single cell
contrast enhanced
phase ii
computed tomography
magnetic resonance imaging
phase iii
deep learning
cognitive decline
current status
open label
machine learning
bone marrow
mesenchymal stem cells
mild cognitive impairment