IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma.

Joanna ObaczJérôme ArchambeauElodie LafontManon NivetSophie MartinMarc AubryKonstantinos VoutetakisRaphael PineauRachel BonifaceDaria SicariDiana Pelizzari-RaymundoGevorg GhukasyanEoghan McGrathEfstathios-Iason VlachavasMatthieu Le GalloPierre Jean Le ResteKim BarrosoTanya Fainsod-LeviAkram ObiedatZvi GranotBoaz TiroshJuhi SamalAbhay PanditLuc NégroniNicolas SorianoAnnabelle MonnierJean MosserAristotelis ChatziioannouVéronique QuillienEric ChevetTony Avril

Published in: Neuro-oncology (2024)

Our work identifies a novel IRE1/UBE2D3 proinflammatory axis that plays an instrumental role in GB immune regulation.

Keyphrases

endoplasmic reticulum stress
single cell
cell therapy
bone marrow
genome wide
acute myeloid leukemia
dendritic cells
dna methylation
stem cells
immune response